Maria Branyas Morera’s life began in San Francisco in 1907 and stretched across 117 remarkable years — a span that saw two world wars, 21 U.S. presidents, and the rise of modern technology. At just eight years old, she moved with her family to Spain, where tragedy struck when her father died of tuberculosis during the journey. Yet Maria’s resilience carried her forward.

In her later years, she became known as the world’s oldest living person, admired not only for her longevity but for her sharp mind and gentle humor. Before her death in 2024, Maria made one final request: that her DNA be studied to help scientists uncover the biological keys to a longer, healthier life. Her wish set a groundbreaking project in motion, uniting researchers from the University of Barcelona and the Josep Carreras Leukaemia Research Institute.

Dr. Manel Esteller, who led the study, described Maria as “an exception to the rule,” noting that she managed to stay healthy even at extreme old age. “For the first time,” he said, “we’ve been able to separate being old from being sick.”

What Science — and Maria — Taught the World

When doctors examined Maria’s DNA and cell samples, they were stunned. Biologically, she appeared 10 to 15 years younger than her actual age. Her cholesterol balance was ideal, her triglycerides were low, and her overall health mirrored that of someone decades her junior.

But Maria’s secret wasn’t only in her genes. She lived with intention — eating well, walking daily, and keeping her mind active through community and family. She also had a small daily ritual: enjoying her favorite yogurt, La Fageda, a probiotic brand known to support gut health and reduce inflammation.

Her unique genetic profile even showed unusual telomere patterns that might have helped protect her from age-related disease. As Dr. Esteller explained, “The clues for extreme longevity are a mix between what we inherit and how we live — maybe half and half.”

Even in her final years, Maria shared wisdom online, writing that the keys to a long life are “order, tranquillity, good connections, emotional stability, positivity, and staying away from toxic people.”

Her legacy now lives on — not just in her descendants, but in the scientific research her life inspired, offering hope that one day, aging and illness may no longer go hand in hand.